Subutex and Tramadol Interaction

Subutex is a partial opioid agonist used to treat those with opioid use disorder or opioid dependency. It does provide mild pain relief and can cause a slight euphoria, but it also has a ceiling effect. Once you get to a certain dose, taking more of the drug will not increase the high you experience.

Tramadol is a medication, similar to opioid analgesics, used to treat moderate to severe pain. It acts on the central nervous system to promote relaxation and feelings of well-being. It is a narcotic and is a Schedule IV controlled substance. This means it does have medicinal benefits, but it can also be addictive.

Subutex and Tramadol Interaction

Dangers Mixing Suboxone and Tramadol

Another thing to note here is that there is a huge difference if someone were to mix Tramadol with Suboxone. Suboxone is a combination medication used to treat opioid use disorder or opioid dependency. Suboxone contains two ingredients, buprenorphine, and naloxone; the naloxone in Suboxone reverses the effects of opioids.

You can take Tramadol after you have taken Suboxone, however, if you take Suboxone after taking Tramadol or any other opioid, you will most likely experience precipitated withdrawal symptoms. The naloxone in Suboxone would reverse the effects of the Tramadol, and the buprenorphine would dislodge the Tramadol or opioid from the receptors and replace it. Precipitated withdrawal is a very awful experience.

One last thing that I think is important to note. Subutex or Suboxone are both 50 times more potent than Morphine, so if you have been taking either medication for a length of time, your opioid tolerance is going to be high. If you are trying to achieve a high by mixing the two drugs, it would take very large doses of Tramadol, and that high of a dose would likely be extremely dangerous.

More on Mixing Subutex and Tramadol

It is dangerous to mix any drugs, period, and mixing Subutex and Tramadol can have deadly effects. Taking two opioids at the same time can increase the risk of an overdose. Also, using Subutex together with Tramadol can significantly increase the risk of seizure activity.

The American Journal on Addictions says:

Drug interactions are a leading cause of morbidity and mortality. Methadone and buprenorphine are frequently prescribed for the treatment of opioid addiction. Patients needing treatment with these medications often have co-occurring medical and mental illnesses that require medication treatment. The abuse of illicit substances is also common in opioid-addicted individuals. These clinical realities place patients being treated with methadone and buprenorphine at risk for potentially toxic drug interactions. A substantial literature has accumulated on drug interactions between either methadone or buprenorphine with other medications when ingested concomitantly by humans. The World Health Organization reports that drug interactions are a leading cause of morbidity and mortality. This finding extends to medications used in the treatment of substance use disorders and pharmacotherapies utilized for the treatment of medical or mental illnesses, as well as for abused substances—including alcohol, licit, and illicit substances. (NIH)

Furthermore, when mixing Tramadol or any other opioid with Subutex, most likely you will not feel the effects. Subutex has a higher binding rate than Tramadol, and it occupies the opioid receptors in the brain.

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